Proliferating cell nuclear antigen(PCNA) as a marker of proliferating cells in salivary gland tumors.
نویسندگان
چکیده
منابع مشابه
A Review of Signet Ring cells in Salivary Gland Tumors
Objectives: Signet Ring Cells (SRCs) are often seen in gastrointestinal, breast, bile duct and lung invasive carcinomas. Observing these cells in benign and malignant lesions of the salivary glands is not common. Signet-ring cell adenocarcinoma is rare and is commonly seen in the secondary salivary glands. Although, the presence of SRCs in other neoplasms of the body is usually associated with ...
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Proliferating cell nuclear antigen (PCNA), an endogenous nuclear protein, has recently been used to identify replicating cells. PCNA was compared to tritiated thymidine ([3H]-TdR), a reliable and accurate exogenous labeling agent, to ascertain if PCNA gives comparable results for quantitative cell proliferation. Male F344 rats were treated with a single dose of 500 mg/kg 4-acetylaminofluorene (...
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After exposure to DNA-damaging agents that block the progress of the replication fork, monoubiquitination of proliferating cell nuclear antigen (PCNA) mediates the switch from replicative to translesion synthesis DNA polymerases. We show that in human cells, PCNA is monoubiquitinated in response to methyl methanesulfonate and mitomycin C, as well as UV light, albeit with different kinetics, but...
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We have used antisense phosphorothioate oligonucleotides to define the role played by proliferating cell nuclear antigen (PCNA) in neointimal accumulation of smooth muscle cells in a rat carotid artery injury model. The short-term extraluminal delivery of 250 nmol of antisense oligonucleotides, but not control oligonucleotides, immediately after arterial injury produces a 77% suppression of PCN...
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ژورنال
عنوان ژورنال: Japanese Journal of Oral Biology
سال: 1992
ISSN: 0385-0137
DOI: 10.2330/joralbiosci1965.34.454